Apache/ColdFusion 9 per-directory application isolation

With CF9 enterprise, I'd like to connect to multiple CF instances in a single Apache virtual host.

For example,

mydomain.com/app1-> handled by instance1
mydomain.com/app2-> handled by instance2

It seems most people accomplish this by using separate vhosts, but I was wondering if this could be done at a directory level.  I've tried using <Directory> and <Location> stanzas with their own JRunConfig directives, but they end up overwriting the JRun config for the entire virtual host.

If anyone knows of a built-in way to accomplish this, I would be interested.  Alternatively, I'd like input on using an Apache reverse proxy configuration so that I can map /app1 to the WebService port of the JRUN instance:

mydomain.com/app1-> localhost:8301/app1
mydomain.com/app2-> localhost:8302/app2

Has anyone had luck with this?  Does anyone see issues with this or have a better idea?

Thanks!
Seth S.